Alzheimer’s disease became well known in 1906 when German physician Alois Alzheimer became dismayed over one of his patient’s behavior. She had come to him in 1901 for treatment. She was a 51 year old woman who had become very confused. She developed problems with speaking and understanding what was being said to her. He worked hard to try to help her, however all of his efforts failed. Her symptoms worsened, and she passed away. He had so many unanswered questions that he requested permission from her family to do an autopsy. The autopsy revealed many things.